Internal medicine

Pathology

Translational medicine

Cancer stem cell

Bioinformatics

Biology

Cancer

Metastasis

Stem cell

Cancer research

Genetics

Medicine

Stem Cells Translational Medicine

Cancer stem cells (CSCs) are a subpopulation of cells within tumors that possess the stem cell characteristics of self-renewal, quiescence, differentiation, and the ability to recapitulate the parental tumor when transplanted into a host. CSCs are correlated with poor clinical outcome due to their contribution to chemotherapy resistance and metastasis. Multiple cell surface and enzymatic markers have been characterized to identify CSCs within a heterogeneous tumor, and here we summarize ongoing preclinical and clinical efforts to therapeutically target these cells and improve patient outcomes. Stem Cells Translational Medicine 2019;8:75-81.

Concise Reviews: Cancer Stem Cell Targeted Therapies: Toward Clinical Success