Original paper
De novo NAD+ synthesis enhances mitochondrial function and improves health
Abstract
Nicotinamide adenine dinucleotide (NAD+) is a co-substrate for several enzymes, including the sirtuin family of NAD+-dependent protein deacylases. Beneficial effects of increased NAD+ levels and sirtuin activation on mitochondrial homeostasis, organismal metabolism and lifespan have been established across species. Here we show that α-amino-β-carboxymuconate-ε-semialdehyde decarboxylase (ACMSD), the enzyme that limits spontaneous cyclization of...
Paper Details
Title
De novo NAD+ synthesis enhances mitochondrial function and improves health
Published Date
Oct 23, 2018
Journal
Volume
563
Issue
7731
Pages
354 - 359