De novo NAD+ synthesis enhances mitochondrial function and improves health

Nature64.80
Volume: 563, Issue: 7731, Pages: 354 - 359
Published: Oct 24, 2018
Abstract
Nicotinamide adenine dinucleotide (NAD+) is a co-substrate for several enzymes, including the sirtuin family of NAD+-dependent protein deacylases. Beneficial effects of increased NAD+ levels and sirtuin activation on mitochondrial homeostasis, organismal metabolism and lifespan have been established across species. Here we show that α-amino-β-carboxymuconate-ε-semialdehyde decarboxylase (ACMSD), the enzyme that limits spontaneous cyclization of...
Paper Details
Title
De novo NAD+ synthesis enhances mitochondrial function and improves health
Published Date
Oct 24, 2018
Journal
Volume
563
Issue
7731
Pages
354 - 359
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