The effects of P2X7 receptor knockout on emotional conditions over the lifespan of mice

Neuroinflammation is one of the key factors contributing to depression. Recent studies have identified P2X7 receptor (P2X7r) as a major inflammatory regulator. However, the effects of P2X7r knockout (KO) on emotional conditions over the lifespan of mice are unknown. In this study, the effects of P2X7r deletion on emotional conditions over the lifespan of mice were investigated in young-aged (2 month old), middle-aged (10 month old), and old-aged...