The intellectual disability gene PQBP1 rescues Alzheimer’s disease pathology

Volume: 23, Issue: 10, Pages: 2090 - 2110
Published: Oct 1, 2018
Abstract
Early-phase pathologies of Alzheimer's disease (AD) are attracting much attention after clinical trials of drugs designed to remove beta-amyloid (Aβ) aggregates failed to recover memory and cognitive function in symptomatic AD patients. Here, we show that phosphorylation of serine/arginine repetitive matrix 2 (SRRM2) at Ser1068, which is observed in the brains of early phase AD mouse models and postmortem end-stage AD patients, prevents its...
Paper Details
Title
The intellectual disability gene PQBP1 rescues Alzheimer’s disease pathology
Published Date
Oct 1, 2018
Volume
23
Issue
10
Pages
2090 - 2110
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