High-throughput in vivo screen of functional mRNA delivery identifies nanoparticles for endothelial cell gene editing
Volume: 115, Issue: 42
Published: Oct 1, 2018
Abstract
Significance Nanoparticle-mediated delivery of siRNA to hepatocytes has treated disease in humans. However, systemically delivering RNA drugs to nonliver tissues remains an important challenge. To increase the number of nanoparticles that could be studied in vivo, we designed a high-throughput method to measure how >100 nanoparticles delivered mRNA that was translated into functional protein in vivo. We quantified how >250 lipid...
Paper Details
Title
High-throughput in vivo screen of functional mRNA delivery identifies nanoparticles for endothelial cell gene editing
Published Date
Oct 1, 2018
Volume
115
Issue
42
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