Structural basis for antiarrhythmic drug interactions with the human cardiac sodium channel

Volume: 116, Issue: 8, Pages: 2945 - 2954
Published: Feb 6, 2019
Abstract
The human voltage-gated sodium channel, hNaV1.5, is responsible for the rapid upstroke of the cardiac action potential and is target for antiarrhythmic therapy. Despite the clinical relevance of hNaV1.5-targeting drugs, structure-based molecular mechanisms of promising or problematic drugs have not been investigated at atomic scale to inform drug design. Here, we used Rosetta structural modeling and docking as well as molecular dynamics...
Paper Details
Title
Structural basis for antiarrhythmic drug interactions with the human cardiac sodium channel
Published Date
Feb 6, 2019
Volume
116
Issue
8
Pages
2945 - 2954
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