Type 2 Diabetes–Associated Genetic Variants Regulate Chromatin Accessibility in Human Islets

Volume: 67, Issue: 11, Pages: 2466 - 2477
Published: Sep 4, 2018
Abstract
Type 2 diabetes (T2D) is a complex disorder in which both genetic and environmental risk factors contribute to islet dysfunction and failure. Genome-wide association studies (GWAS) have linked single nucleotide polymorphisms (SNPs), most of which are noncoding, in >200 loci to islet dysfunction and T2D. Identification of the putative causal variants and their target genes and whether they lead to gain or loss of function remains...
Paper Details
Title
Type 2 Diabetes–Associated Genetic Variants Regulate Chromatin Accessibility in Human Islets
Published Date
Sep 4, 2018
Journal
Volume
67
Issue
11
Pages
2466 - 2477
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