Original paper

Evaluation of 244,000 synthetic sequences reveals design principles to optimize translation in Escherichia coli

Volume: 36, Issue: 10, Pages: 1005 - 1015
Published: Sep 24, 2018
Abstract
Comparative analyses of natural and mutated sequences have been used to probe mechanisms of gene expression, but small sample sizes may produce biased outcomes. We applied an unbiased design-of-experiments approach to disentangle factors suspected to affect translation efficiency in E. coli. We precisely designed 244,000 DNA sequences implementing 56 replicates of a full factorial design to evaluate nucleotide, secondary structure, codon and...
Paper Details
Title
Evaluation of 244,000 synthetic sequences reveals design principles to optimize translation in Escherichia coli
Published Date
Sep 24, 2018
Volume
36
Issue
10
Pages
1005 - 1015
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