Apoε4 disrupts neurovascular regulation and undermines white matter integrity and cognitive function
Abstract
The ApoE4 allele is associated with increased risk of small vessel disease, which is a cause of vascular cognitive impairment. Here, we report that mice with targeted replacement (TR) of the ApoE gene with human ApoE4 have reduced neocortical cerebral blood flow compared to ApoE3-TR mice, an effect due to reduced vascular density rather than slowing of microvascular red blood cell flow. Furthermore, homeostatic mechanisms matching local delivery...
Paper Details
Title
Apoε4 disrupts neurovascular regulation and undermines white matter integrity and cognitive function
Published Date
Sep 19, 2018
Journal
Volume
9
Issue
1
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