Original paper

Mitochondrial Function Is Compromised in Cortical Bone Osteocytes of Long‐Lived Growth Hormone Receptor Null Mice

Volume: 34, Issue: 1, Pages: 106 - 122
Published: Sep 14, 2018
Abstract
Despite increased longevity and resistance to multiple stressors, growth hormone receptor null (GHRKO) mice exhibit severe skeletal impairment. The role of GHR in maintaining osteocyte mitochondrial function is unknown. We found that GHR ablation was detrimental to osteocyte mitochondrial function. In vivo multiphoton microscopy revealed significant reductions of >10% in mitochondrial membrane potential (MMP) in GHRKO osteocytes and reduced...
Paper Details
Title
Mitochondrial Function Is Compromised in Cortical Bone Osteocytes of Long‐Lived Growth Hormone Receptor Null Mice
Published Date
Sep 14, 2018
Volume
34
Issue
1
Pages
106 - 122
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