Propagation and spread of pathogenic protein assemblies in neurodegenerative diseases

Volume: 21, Issue: 10, Pages: 1341 - 1349
Published: Sep 26, 2018
Abstract
Many neurodegenerative diseases, such as Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis, are characterized by the progressive appearance of abnormal proteinaceous assemblies in the nervous system. Studies in experimental systems indicate that the assemblies originate from the prion-like seeded aggregation of specific misfolded proteins that proliferate and amass to form the intracellular and/or extracellular lesions...
Paper Details
Title
Propagation and spread of pathogenic protein assemblies in neurodegenerative diseases
Published Date
Sep 26, 2018
Volume
21
Issue
10
Pages
1341 - 1349
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