Minimum structural requirements for BMP-2-binding of heparin oligosaccharides

Bone morphogenetic proteins (BMPs) are essential during tissue repair and remodeling after injury . Glycosaminoglycan (GAG) sugars are known to enhance BMP activity in vitro and in vivo; here the interactions of BMP-2 with various glycosaminoglycan classes were compared and shown to be selective for heparin over other comparable saccharides . The minimal chain lengths and specific sulfate moieties required for heparin-derived oligosaccharide...