Minimum structural requirements for BMP-2-binding of heparin oligosaccharides

Volume: 184, Pages: 41 - 55
Published: Nov 1, 2018
Abstract
Bone morphogenetic proteins (BMPs) are essential during tissue repair and remodeling after injury. Glycosaminoglycan (GAG) sugars are known to enhance BMP activity in vitro and in vivo; here the interactions of BMP-2 with various glycosaminoglycan classes were compared and shown to be selective for heparin over other comparable saccharides. The minimal chain lengths and specific sulfate moieties required for heparin-derived oligosaccharide...
Paper Details
Title
Minimum structural requirements for BMP-2-binding of heparin oligosaccharides
Published Date
Nov 1, 2018
Volume
184
Pages
41 - 55
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