A Study of NMR-Based Hepatic and Serum Metabolomics in a Liver Injury Sprague–Dawley Rat Model Induced by Psoralen

Psoralen is the main active component of Psoralea corylifolia and is used as a marker to assess its quality. The effects of psoralen on animals have been well characterized. However, the molecular pathway of its toxicity is not fully understood. In this study, the toxic effects of psoralen administration (60 mg/kg) for 7 days in Sprague–Dawley rats were observed. Serum biochemistry and liver histopathology were further investigated. Proton...