Internal medicine

Prophylactic cranial irradiation

Conventional PCI

Myocardial infarction

Biology

Meta-analysis

Cancer

Surgery

Oncology

Stage (stratigraphy)

Paleontology

Survival rate

Lung

Lung cancer

Radiation therapy

Medicine

Radiation Oncology

A recent Japanese study suggested prophylactic cranial irradiation (PCI) failed to improve survival of extensive-stage small-cell lung cancer (SCLC). However, previous studies showed that PCI was beneficial in reducing the rate of mortality for extensive-stage SCLC. In this study, we aimed to evaluate the impact of PCI on the survival of patients diagnosed with extensive-stage SCLC by meta-analysis.

The effects of prophylactic cranial irradiation versus control on survival of patients with extensive-stage small-cell lung cancer: a meta-analysis of 14 trials