Radiation Oncology
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#1Jing Jia (Capital Medical University)
#2Wenming Chen (Capital Medical University)
BACKGROUD Primary tonsil diffuse large B cell lymphoma (PT-DLBCL) is an uncommon disease entity. The role of radiation therapy (RT) in PT-DLBCL is debatable in both the pre- and post- rituximab era. The purpose of this study was to evaluate the treatment outcome and establish a prognostic model in PT-DLBCL based on the Surveillance, Epidemiology, and End Results (SEER) database. MATERIALS AND METHODS Data of 1214 PT-DLBCL patients diagnosed between 1975 and 2016 were extracted from SEER 18. The ...
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#1Oliver Vilinovszki (UZH: University of Zurich)
#2Nicolaus Andratschke (UZH: University of Zurich)H-Index: 31
Last. Stephanie G. C. Kroeze (UZH: University of Zurich)H-Index: 9
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BACKGROUND Systemic response to local anticancer treatment is a phenomenon called 'abscopal effect'. The immune system is thought to play a pivotal role in its occurrence. To date, several cases have been reported, particularly in patients receiving combined local treatment and immune checkpoint inhibitors. In such cases, it is impossible to discriminate between the effects of local and systemic treatment. Only a few cases of abscopal effect have been described with radiotherapy alone. CASE PRES...
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#1Michael Sørensen (Aarhus University Hospital)H-Index: 21
#2Mette Marie Fode (Aarhus University Hospital)H-Index: 4
Last. Morten Høyer (Aarhus University Hospital)H-Index: 43
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Purpose null Stereotactic body radiotherapy (SBRT) is increasingly used for treatment of liver tumors but the effect on metabolic liver function in surrounding tissue is largely unknown. Using 2-deoxy-2-[18F]fluoro-D-galactose ([18F]FDGal) positron emission tomography (PET)/computed tomography (CT), we aimed to determine a dose-response relationship between radiation dose and metabolic liver function as well as recovery. null Procedures null One male subject with intrahepatic cholangiocarcinoma ...
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Glioblastoma is the most common primary brain malignancy and carries with it a poor prognosis. New agents are urgently needed, however nearly all Phase III trials of GBM patients of the past 25 years have failed to demonstrate improvement in outcomes. In 2019, the National Cancer Institute Clinical Trials and Translational Research Advisory Committee (CTAC) Glioblastoma Working Group (GBM WG) identified 5 broad areas of research thought to be important in the development of new herapeutics for G...
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#1D.J. den Boer (UvA: University of Amsterdam)H-Index: 1
#2Johannes K. Veldman (UvA: University of Amsterdam)
Last. Zdenko van Kesteren (UvA: University of Amsterdam)H-Index: 4
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BACKGROUND In radiotherapy, respiratory-induced tumor motion is typically measured using a single four-dimensional computed tomography acquisition (4DCT). Irregular breathing leads to inaccurate motion estimates, potentially resulting in undertreatment of the tumor and unnecessary dose to healthy tissue. The aim of the research was to determine if a daily pre-treatment 4DMRI-strategy led to a significantly improved motion estimate compared to single planning 4DMRI (with or without outlier reject...
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#1Jana Schaule (UZH: University of Zurich)H-Index: 1
#2M. Chamberlain (UZH: University of Zurich)H-Index: 3
Last. M. Guckenberger (UZH: University of Zurich)H-Index: 5
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BACKGROUND MR-guided online adaptive stereotactic body radiation therapy (SBRT) for prostate cancer aims to reduce toxicity by full compensation of interfractional uncertainties. However, the process of online adaptation currently takes approximately 45 min during which intrafractional movements remain unaccounted for. This study aims to analyze the dosimetric benefit of online adaptation and to evaluate its robustness over the duration of one treatment fraction. METHODS Baseline MR-scans at a M...
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#1Lina Wang (Lanzhou University)H-Index: 1
#2Xiaohu Wang (Lanzhou University)H-Index: 8
Last. Zheng Yang (Lanzhou University)
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Pelvic radiotherapy is the key treatment for pelvic malignancies, usually including pelvic primary tumour lesions and lymphatic drainage areas in the pelvic region. Therefore, the intestinal tract in the radiation field is inevitably damaged, a phenomenon clinically referred to as radiation enteritis, and diarrhoea is the most common clinical symptom of radiation enteritis. Therefore, it is necessary to study the mechanism of radiation-induced diarrhoea. It has been found that the gut microbiome...
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#1Francesco CucciaH-Index: 7
#2Filippo Alongi (University of Brescia)H-Index: 33
Last. Judith Slagter (UvA: University of Amsterdam)
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Hybrid magnetic resonance (MR)-guided linear accelerators represent a new horizon in the field of radiation oncology. By harnessing the favorable combination of on-board MR-imaging with the possibility to daily recalculate the treatment plan based on real-time anatomy, the accuracy in target and organs-at-risk identification is expected to be improved, with the aim to provide the best tailored treatment. To date, two main MR-linac hybrid machines are available, Elekta Unity and Viewray MRIdian. ...
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#1Xia Wang (NCU: Nanchang University)H-Index: 1
#2Jiaqi Song (NCU: Nanchang University)
Last. Anwen Liu (NCU: Nanchang University)H-Index: 8
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Background null The role of postoperative radiotherapy (PORT) in cardiovascular-pulmonary disease mortality in patients with stage IIIA-N2 resected non-small cell lung cancer (NSCLC) remains uncertain. The purpose of this population-based analysis was to explore the effect of PORT on cardiovascular-pulmonary disease mortality in these patients. null Methods null Patients aged ≥ 18 years with stage IIIA-N2 resected NSCLC were identified in the Surveillance, Epidemiology, and End Results (SEER) da...
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#1Qing-Song He (Ha Tai: Xiamen University)
#2Zhen-Ping Wang (HMU: Hainan Medical University)
Last. Si-Fang Chen (Ha Tai: Xiamen University)
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BACKGROUND To investigate the relationship between radiotherapy (RT) and the risk of cerebrovascular mortality (CVM) in head and neck cancer (HNC) survivors aged ≥ 65 years. METHODS Patients with HNC survivors aged ≥ 65 years diagnosed between 2000 and 2012 were included from the Surveillance, Epidemiology, and End Results database. Kaplan-Meier analysis, Log-rank tests, and Cox proportional-hazards regression models were performed for statistical analyses. RESULTS We included 16,923 patients in...
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