Nuclear-resident RIG-I senses viral replication inducing antiviral immunity
Abstract
The nucleus represents a cellular compartment where the discrimination of self from non-self nucleic acids is vital. While emerging evidence establishes a nuclear non-self DNA sensing paradigm, the nuclear sensing of non-self RNA, such as that from nuclear-replicating RNA viruses, remains unexplored. Here, we report the identification of nuclear-resident RIG-I actively involved in nuclear viral RNA sensing. The nuclear RIG-I, along with its...
Paper Details
Title
Nuclear-resident RIG-I senses viral replication inducing antiviral immunity
Published Date
Aug 10, 2018
Journal
Volume
9
Issue
1
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