Nuclear pore heterogeneity influences HIV-1 infection and the antiviral activity of MX2

eLife7.70
Volume: 7
Published: Aug 7, 2018
Abstract
HIV-1 accesses the nuclear DNA of interphase cells via a poorly defined process involving functional interactions between the capsid protein (CA) and nucleoporins (Nups). Here, we show that HIV-1 CA can bind multiple Nups, and that both natural and manipulated variation in Nup levels impacts HIV-1 infection in a manner that is strikingly dependent on cell-type, cell-cycle, and cyclophilin A (CypA). We also show that Nups mediate the function of...
Paper Details
Title
Nuclear pore heterogeneity influences HIV-1 infection and the antiviral activity of MX2
Published Date
Aug 7, 2018
Journal
Volume
7
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