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Original paper

An amphipathic cyclic tetrapeptide scaffold containing halogenated β2,2‐amino acids with activity against multiresistant bacteria

Volume: 24, Issue: 10
Published: Aug 15, 2018
Abstract
The present study describes the synthesis and biological studies of a small series of head‐to‐tail cyclic tetrapeptides of the general structure c(Lys‐β 2,2 ‐Xaa‐Lys) containing one lipophilic β 2,2 ‐amino acid and Lys, Gly, Ala, or Phe as the Xaa residue in the sequence. The peptides were investigated for antimicrobial activity against gram‐positive and gram‐negative reference strains and 30 multiresistant clinical isolates including strains...
Paper Details
Title
An amphipathic cyclic tetrapeptide scaffold containing halogenated β2,2‐amino acids with activity against multiresistant bacteria
Published Date
Aug 15, 2018
Volume
24
Issue
10
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