Pathogenesis of Cushing Disease: An Update on the Genetics of Corticotropinomas

Objective: Cushing disease is a rare severe condition caused by pituitary tumors that secrete adrenocorticotropic hormone (ACTH), leading to excessive endogenous glucocorticoid production. Tumors causing Cushing disease, also called corticotropinomas, are typically monoclonal neoplasms that mainly occur sporadically. Methods: Literature review. Results: Cushing disease is very rarely encountered in genetic familial syndromes. Oncogenes and tumor...