Lathyrane-Type Diterpenoids from the Seeds of Euphorbia lathyris L. with Inhibitory Effects on NO Production in RAW 264.7 Cells.

Published on Oct 1, 2018in Chemistry & Biodiversity2.039
· DOI :10.1002/CBDV.201800144
Jin Woo Lee13
Estimated H-index: 13
(CBNU: Chungbuk National University),
Qinghao Jin13
Estimated H-index: 13
(CBNU: Chungbuk National University)
+ 6 AuthorsBang Yeon Hwang37
Estimated H-index: 37
(CBNU: Chungbuk National University)
Sources
Abstract
: Bioactivity-guided fractionation of the methanolic extract from the seeds of Euphorbia lathyris led to the isolation of 18 lathyrane-type diterpenoids including a new one, Euphorbia factor L29 (1). Their chemical structures were elucidated by extensive NMR spectroscopic data including 2D-NMR and HR-ESI-MS as well as CD data. All isolates (1 - 18) were found to inhibit the nitric oxide production in LPS-induced RAW 264.7 macrophages, with their IC50 values in the range of 11.2 - 52.2 μm.
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