Substance P Receptor in the Rat Heart and Regulation of Its Expression in Long-Term Diabetes

Substance P (SP) is involved in the transmission of neural afferents of C fibers in the myocardium. The actions of SP in the heart are extensive and they are mediated by the NK1 receptor, a member of the tachykinin subfamily of G-protein coupled receptors. The receptors have been found in the heart, but to our knowledge, their exact localization in the heart has not been described yet. Here, we investigated presence of NK1 receptor protein in...