Original paper
Regulation of T cell expansion by antigen presentation dynamics
Volume: 116, Issue: 13, Pages: 5914 - 5919
Published: Mar 8, 2019
Abstract
Significance Antigen-specific T cells proliferate multiple times during an immune reaction to fight against disease. This expansion of T cells must be carefully regulated to ensure an effective defense while avoiding autoimmunity. One challenge to regulation is that the initial size of antigen-specific T cell clones can be quite variable. Intriguingly, a recent study in mice found that the fold expansion of a T cell clone depends as an inverse...
Paper Details
Title
Regulation of T cell expansion by antigen presentation dynamics
Published Date
Mar 8, 2019
Volume
116
Issue
13
Pages
5914 - 5919