18F-PBR06 Versus 11C-PBR28 PET for Assessing White Matter Translocator Protein Binding in Multiple Sclerosis

Background and Purpose 18 F-PBR06 and 11 C-PBR28 are second-generation PET radioligands targeting the 18-kd translocator protein to assess microglial activation. We directly compared 18 F-PBR06 and 11 C-PBR28 for detecting brain translocator protein binding in multiple sclerosis (MS). Methods Six patients with MS (4 women; mean age ± SD, 32.1 ± 4.9 [range, 23.5–37.4 years]; Expanded Disability Status Scale score 2.3 ± 1.2 [range, 1.0–4.0])...