Glutathione depletion induces ferroptosis, autophagy, and premature cell senescence in retinal pigment epithelial cells
Abstract
Glutathione (GSH) protects against oxidative damage in many tissues, including retinal pigment epithelium (RPE). Oxidative stress-mediated senescence and death of RPE and subsequent death of photoreceptors have been observed in age-related macular degeneration (AMD). Although the consequences of GSH depletion have been described previously, questions remain regarding the molecular mechanisms. We herein examined the downstream effects of GSH...
Paper Details
Title
Glutathione depletion induces ferroptosis, autophagy, and premature cell senescence in retinal pigment epithelial cells
Published Date
Jul 9, 2018
Journal
Volume
9
Issue
7
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