Estrogen-regulated feedback loop limits the efficacy of estrogen receptor–targeted breast cancer therapy

Volume: 115, Issue: 31, Pages: 7869 - 7878
Published: Jul 9, 2018
Abstract
Endocrine therapy resistance invariably develops in advanced estrogen receptor-positive (ER+) breast cancer, but the underlying mechanisms are largely unknown. We have identified C-terminal SRC kinase (CSK) as a critical node in a previously unappreciated negative feedback loop that limits the efficacy of current ER-targeted therapies. Estrogen directly drives CSK expression in ER+ breast cancer. At low CSK levels, as is the case in patients...
Paper Details
Title
Estrogen-regulated feedback loop limits the efficacy of estrogen receptor–targeted breast cancer therapy
Published Date
Jul 9, 2018
Volume
115
Issue
31
Pages
7869 - 7878
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