The Conformation of the Mannopyranosyl Phosphate Repeating Unit of the Capsular Polysaccharide ofNeisseria meningitidisSerogroup A and Its Carba-Mimetic

Neisseria meningitidis serogroup A (MenA) is an aerobic diplococcal Gram‐negative bacterium responsible for epidemic meningitis disease. Its capsular polysaccharide (CPS) has been identified as the primary virulence factor of MenA. This polysaccharide suffers from chemical lability in water. Thus, the design and synthesis of novel and hydrolytically stable structural analogues of MenA CPS may provide additional tools for the development of...