Enhancing T cell therapy through TCR-signaling-responsive nanoparticle drug delivery
Abstract
Adoptive cell therapy (ACT) with antigen-specific T cells has shown remarkable clinical success; however, approaches to safely and effectively augment T cell function, especially in solid tumors, remain of great interest. Here we describe a strategy to 'backpack' large quantities of supporting protein drugs on T cells by using protein nanogels (NGs) that selectively release these cargos in response to T cell receptor activation. We designed cell...
Paper Details
Title
Enhancing T cell therapy through TCR-signaling-responsive nanoparticle drug delivery
Published Date
Jul 9, 2018
Journal
Volume
36
Issue
8
Pages
707 - 716
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Notes
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