Challenges with the precise prediction of ABC-transporter interactions for improved drug discovery

Introduction: Given that membrane efflux transporters can influence a drug’s pharmacokinetics, efficacy and safety, identifying potential substrates and inhibitors of these transporters is a critical element in the drug discovery and development process. Additionally, it is important to predict the inhibition potential of new drugs to avoid clinically significant drug interactions. The goal of preclinical studies is to characterize a new drug as...