Skeletal Muscle Stem Cells from PSC-Derived Teratomas Have Functional Regenerative Capacity

Volume: 23, Issue: 1, Pages: 74 - 85.e6
Published: Jul 1, 2018
Abstract
Derivation of functional skeletal muscle stem cells from pluripotent cells without genetic modification has proven elusive. Here we show that teratomas formed in adult skeletal muscle differentiate in vivo to produce large numbers of α7-Integrin+ VCAM-1+ myogenic progenitors. When FACS-purified and transplanted into diseased muscles, mouse teratoma-derived myogenic progenitors demonstrate very high engraftment potential. As few as 40,000 cells...
Paper Details
Title
Skeletal Muscle Stem Cells from PSC-Derived Teratomas Have Functional Regenerative Capacity
Published Date
Jul 1, 2018
Volume
23
Issue
1
Pages
74 - 85.e6
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