Classifying tumors by supervised network propagation
Abstract
Motivation Network propagation has been widely used to aggregate and amplify the effects of tumor mutations using knowledge of molecular interaction networks. However, propagating mutations through interactions irrelevant to cancer leads to erosion of pathway signals and complicates the identification of cancer subtypes. Results To address this problem we introduce a propagation algorithm, Network-Based Supervised Stratification (NBS2), which...
Paper Details
Title
Classifying tumors by supervised network propagation
Published Date
Jun 27, 2018
Journal
Volume
34
Issue
13
Pages
i484 - i493
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Notes
History