Elevated levels of 2-arachidonoylglycerol promote atherogenesis in ApoE-/- mice
Abstract
Background The endocannabinoid (eCB) 2-arachidonoylglycerol (2-AG) is a known modulator of inflammation and ligand to both, pro-inflammatory cannabinoid receptor 1 (CB1) and anti-inflammatory CB2. While the role of both receptors in atherogenesis has been studied extensively, the significance of 2-AG for atherogenesis is less well characterized. Methods The impact of 2-AG on atherogenesis was studied in two treatment groups of ApoE-/- mice. One...
Paper Details
Title
Elevated levels of 2-arachidonoylglycerol promote atherogenesis in ApoE-/- mice
Published Date
May 29, 2018
Journal
Volume
13
Issue
5
Pages
e0197751 - e0197751
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