A Modified System for the Synthesis of Enantioenriched N‐Arylamines through Copper‐Catalyzed Hydroamination

Despite significant recent progress in copper‐catalyzed enantioselective hydroamination chemistry, the synthesis of chiral N ‐arylamines, which are frequently found in natural products and pharmaceuticals, has not been realized. Initial experiments with N ‐arylhydroxylamine ester electrophiles were unsuccessful and, instead, their reduction in the presence of copper hydride (CuH) catalysts was observed. Herein, we report key modifications to our...