Original paper
Deciphering the late steps of rifamycin biosynthesis
Abstract
Rifamycin-derived drugs, including rifampin, rifabutin, rifapentine, and rifaximin, have long been used as first-line therapies for the treatment of tuberculosis and other deadly infections. However, the late steps leading to the biosynthesis of the industrially important rifamycin SV and B remain largely unknown. Here, we characterize a network of reactions underlying the biosynthesis of rifamycin SV, S, L, O, and B. The two-subunit...
Paper Details
Title
Deciphering the late steps of rifamycin biosynthesis
Published Date
Jun 14, 2018
Journal
Volume
9
Issue
1
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Notes
History