NRG1 Fusions in KRAS Wild-Type Pancreatic Cancer
Abstract
We used whole-genome and transcriptome sequencing to identify clinically actionable genomic alterations in young adults with pancreatic ductal adenocarcinoma (PDAC). Molecular characterization of 17 patients with PDAC enrolled in a precision oncology program revealed gene fusions amenable to pharmacologic inhibition by small-molecule tyrosine kinase inhibitors in all patients with KRAS wild-type (KRASWT) tumors (4 of 17). These alterations...
Paper Details
Title
NRG1 Fusions in KRAS Wild-Type Pancreatic Cancer
Published Date
Sep 1, 2018
Journal
Volume
8
Issue
9
Pages
1087 - 1095
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