FGFR4 Links Glucose Metabolism and Chemotherapy Resistance in Breast Cancer

Poor response to chemotherapy leads to the relapse and metastatic progression of tumors. Reprogrammed glucose metabolism is one of the important hallmarks of cancer that facilitates cancer cell survival, proliferation and chemoresistance. However, the precise fate of glucose metabolism and its role in therapy responsiveness in cancers remains largely unexplored.The glycolytic phenotype of doxorubicin (ADR)-resistant breast cancer cells and their...