Cellular Physiology and Biochemistry
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#1Martyna Wojtala (University of Łódź)H-Index: 6
#2Dorota Rybaczek (University of Łódź)H-Index: 10
Last. Aneta Balcerczyk (University of Łódź)H-Index: 21
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BACKGROUND/AIMS Inflammation is the body's natural response to stress in the broadest sense. The regulatory mechanisms that control this process, some of which are still unclear, are needed to balance the immune response, but also when insufficient, can cause immunodeficiency resulting in infection, cancer, neurodegeneration or other serious disorders. In this study, we focused on defining the role of lysine-specific demethylase 1 (LSD1), an enzyme involved in modulating the methylation state of...
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#1Christina Wohlrab (University of Otago)H-Index: 5
#2Margreet C. M. Vissers (University of Otago)H-Index: 25
Last. Gabi U. Dachs (University of Otago)H-Index: 28
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BACKGROUND/AIMS Maintenance of whole-body ascorbate levels and distribution is mediated via sodium-dependent vitamin C transporters (SVCTs). The kidney is one of a few organs that express both SVCT1 and SVCT2. Recent evidence suggests that accumulation of ascorbate may be different in tumour compared to normal tissue, but data on SVCT levels in tumours is sparse. METHODS The role of the two SVCT isoforms in ascorbate uptake in renal cell carcinoma (RCC) was investigated in vitro and in clinical ...
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#1Stephenie H. Droll (NU: Northwestern University)
#2Xiaomin Bao (NU: Northwestern University)
Nearly two million cases of cutaneous squamous cell carcinoma (cSCC) are diagnosed every year in the United States alone. cSCC is notable for both its prevalence and its propensity for invasion and metastasis. For many patients, surgery is curative. However, patients experiencing immunosuppression or recurrent, advanced, and metastatic disease still face limited therapeutic options and significant mortality. cSCC forms after decades of sun exposure and possesses the highest known mutation rate o...
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#1Lukas Heintz (UHH: University of Hamburg)
#2Catherine Meyer-Schwesinger (UHH: University of Hamburg)H-Index: 30
Protein homeostasis strongly depends on the targeted and selective removal of unneeded or flawed proteins, of protein aggregates, and of damaged or excess organelles by the two main intracellular degradative systems, namely the ubiquitin proteasomal system (UPS) and the autophagosomal lysosomal system. Despite representing completely distinct mechanisms of degradation, which underlie differing regulatory mechanisms, growing evidence suggests that the UPS and autophagy strongly interact especiall...
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#1Michela Terlizzi (UNISA: University of Salerno)H-Index: 12
#2Chiara Colarusso (UNISA: University of Salerno)H-Index: 9
Last. Rosalinda Sorrentino (UNISA: University of Salerno)H-Index: 25
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BACKGROUND/AIMS The pleiotropic lipid mediator sphingosine-1-phosphate (S1P) exerts a multitude of effects on respiratory cell physiology and pathology through five S1P receptors (S1PR1-5). Epidemiological studies proved high levels of circulating S1P in non-small cell lung cancer (NSCLC) patients. Studies in literature suggest that high levels of S1P support carcinogenesis but the exact mechanism is still elusive. The aim of this study was to understand the mechanism/s underlying S1P-mediated l...
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#1Dongwoo Hahn (UF: University of Florida)H-Index: 3
#2Ravi A. Kumar (UF: University of Florida)H-Index: 3
Last. Leonardo F. Ferreira (UF: University of Florida)H-Index: 33
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Background/aims null Diaphragm dysfunction with increased reactive oxygen species (ROS) occurs within 72 hrs post-myocardial infarction (MI) in mice and may contribute to loss of inspiratory maximal pressure and endurance in patients. null Methods null We used wild-type (WT) and whole-body Nox4 knockout (Nox4KO) mice to measure diaphragm bundle force in vitro with a force transducer, mitochondrial respiration in isolated fiber bundles with an O2 sensor, mitochondrial ROS by fluorescence, mRNA (R...
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#1Daisuke Kobayashi (Fukushima Medical University)H-Index: 9
#2Natsumi Nishimura (Fukushima Medical University)
Last. Akihiro Hazama (Fukushima Medical University)H-Index: 10
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Background/aims null Cesium (Cs) is an alkali metal element that is of no essential use for humans; it has no known beneficial function that is verified by clinical research. When used as an alternative cancer therapy, it even causes toxicity in high doses. Thus, before using Cs as treatment in clinical settings, it is important to clearly determine its biological effects on cells. However, Cs was found to suppress the proliferation of human cervical cancer cells in a dose-dependent manner, and ...
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#1Bruna Dias de Lima Fragelli (UFSCar: Federal University of São Carlos)
#2Luciana Camillo (UFSCar: Federal University of São Carlos)H-Index: 1
Last. Fernanda de Freitas Anibal (UFSCar: Federal University of São Carlos)H-Index: 14
view all 9 authors...
Background/aims null Cancer is the second most deadly disease in the world. The bladder cancer is one of the most aggressive types and shows a continuous increase in the number of cases. The use of bacteria as live vectors to deliver molecules directly to the tumor is a promising tool and has been used as an adjuvant treatment against several types of cancer. The aim of this study was to investigate the antitumor effect of Interleukin 2 (IL-2), TNF-related apoptosis-inducing ligand (TRAIL) and p...
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#1Rían W. Manville (UCI: University of California, Irvine)H-Index: 8
#2Geoffrey W. Abbott (UCI: University of California, Irvine)H-Index: 33
Background/aims null The Amyloid Precursor Protein (APP) is involved in the regulation of multiple cellular functions via protein-protein interactions and has been most studied with respect to Alzheimer's disease (AD). Abnormal processing of the single transmembrane-spanning C99 fragment of APP contributes to the formation of amyloid plaques, which are causally related to AD. Pathological C99 accumulation is thought to associate with early cognitive defects in AD. Here, unexpectedly, sequence an...
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#1Gabriela Ferreira Dias (PUCPR: Pontifícia Universidade Católica do Paraná)H-Index: 3
#2Sara Soares Tozoni (PUCPR: Pontifícia Universidade Católica do Paraná)H-Index: 2
Last. Andrea N Moreno-Amaral (PUCPR: Pontifícia Universidade Católica do Paraná)H-Index: 9
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BACKGROUND/AIMS Chronic kidney disease is frequently accompanied by anemia, hypoxemia, and hypoxia. It has become clear that the impaired erythropoietin production and altered iron homeostasis are not the sole causes of renal anemia. Eryptosis is a process of red blood cells (RBC) death, like apoptosis of nucleated cells, characterized by Ca2+ influx and phosphatidylserine (PS) exposure to the outer RBC membrane leaflet. Eryptosis can be induced by uremic toxins and occurs before senescence, thu...
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