Cellular Physiology and Biochemistry
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#1Owais M. Bhat (VCU: Virginia Commonwealth University)H-Index: 9
#2Pin-Lan Li (VCU: Virginia Commonwealth University)H-Index: 52
The lysosome is a single ubiquitous membrane-enclosed intracellular organelle with an acidic pH present in all eukaryotic cells, which contains large numbers of hydrolytic enzymes with their maximal enzymatic activity at a low pH (pH ≤ 5) such as proteases, nucleases, and phosphatases that are able to degrade extracellular and intracellular components. It is well known that lysosomes act as a center for degradation and recycling of large numbers of macromolecules delivered by endocytosis, phagoc...
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#1Juan Diez (NSU: Nova Southeastern University)H-Index: 18
#2Sumitha Rajendrarao (Scripps Health)
Last. Dmitriy Minond (NSU: Nova Southeastern University)H-Index: 2
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BACKGROUND/AIMS Despite recent advances in melanoma drug discovery, the average overall survival of patients with late-stage metastatic melanoma is approximately 3 years, suggesting a need for new approaches and melanoma therapeutic targets. Previously we identified heterogeneous nuclear ribonucleoprotein H2 as a potential target of anti-melanoma compound 2155-14 (Palrasu et al., Cell Physiol Biochem 2019;53:656-686). In the present study, we endeavored to develop an assay to enable a high throu...
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#1Alyssa Aebersold (University of Louisville)
#2Max Duff (University of Louisville)
Last. Zhao-Hui Song (University of Louisville)
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Cannabidiol (CBD), the major non-intoxicating constituent of Cannabis sativa, has gained recent attention due to its putative therapeutic uses for a wide variety of diseases. CBD was discovered in the 1940s and its structure fully characterized in the 1960s. However, for many years most research efforts related to cannabis derived chemicals have focused on D9-tetrahydrocannabinol (THC). In contrast to THC, the lack of intoxicating psychoactivity associated with CBD highlights the potential of th...
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#1Joseph Boachie (Warw.: University of Warwick)H-Index: 1
#2Antonysunil Adaikalakoteswari (Warw.: University of Warwick)H-Index: 16
Last. Ponnusamy Saravanan (Warw.: University of Warwick)H-Index: 21
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BACKGROUND/AIMS Rise in global incidence of obesity impacts metabolic health. Evidence from human and animal models show association of vitamin B12 (B12) deficiency with elevated BMI and lipids. Human adipocytes demonstrated dysregulation of lipogenesis by low B12 via hypomethylation and altered microRNAs. It is known de novo hepatic lipogenesis plays a key role towards dyslipidaemia, however, whether low B12 affects hepatic metabolism of lipids is not explored. METHODS HepG2 was cultured in B12...
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Apoptosis is a programmed form of cell death culminating in packing cell content and corpse dismantling into membrane sealed vesicles called apoptotic bodies (ABs). Apoptotic bodies are engulfed and disposed by neighboring and immune system cells without eliciting a noxious inflammatory response, thus preventing sterile tissue damage. AB formation requires a total surface area larger than the apparent, initial cell's surface area. Apoptotic volume decrease (AVD) is a two-stage process leading to...
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#1Namir Shaabani (Scripps Research Institute)H-Index: 13
#2Vincent F. Vartabedian (Scripps Research Institute)H-Index: 8
Last. John R. Teijaro (Scripps Research Institute)H-Index: 31
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BACKGROUND/AIMS During an immune response, type I interferon (IFN-I) signaling induces a wide range of changes, including those which are required to overcome viral infection and those which suppress cytotoxic T cells to avoid immunopathology. During certain bacterial infections, IFN-I signaling exerts largely detrimental effects. Although the IFN-I family of proteins all share one common receptor, biologic responses to signaling vary depending on IFN-I subtype. Here, we asked if one IFN-I subty...
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#1Cara Brown (Edin.: University of Edinburgh)H-Index: 1
#2Linda J. Mullins (Edin.: University of Edinburgh)H-Index: 20
Last. John J. Mullins (Edin.: University of Edinburgh)H-Index: 56
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BACKGROUND/AIMS The role of podocytes is well conserved across species from drosophila to teleosts, and mammals. Identifying the molecular markers that actively maintain the integrity of the podocyte will enable a greater understanding of the changes that lead to damage. METHODS We generated transgenic zebrafish, expressing fluorescent reporters driven by the podocin promoter, for the visualization and isolation of podocytes. We have conducted single cell RNA sequencing (scRNA-seq) on isolated p...
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#1Michela Terlizzi (UNISA: University of Salerno)H-Index: 11
#2Chiara Colarusso (UNISA: University of Salerno)H-Index: 7
Last. Rosalinda Sorrentino (UNISA: University of Salerno)H-Index: 25
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Background/aims Sphingosine-1-phosphate (S1P) is a membrane-derived bioactive phospholipid involved in many lung physiological and pathological processes. Higher levels of S1P have been registered in a broad range of respiratory diseases, including inflammatory disorders and cancer. The aim of our study was to understand the role of S1P in healthy versus tumor cells after Toll-Like Receptors (TLRs) activation, well-known modulators of sphingolipid metabolism. Methods Lung adenocarcinoma cells an...
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#1Ardo Sanjaya (Maranatha Christian University)H-Index: 1
#2Hanna Goenawan (UNPAD: Padjadjaran University)H-Index: 4
Last. Ronny Lesmana (UNPAD: Padjadjaran University)H-Index: 8
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Yes-associated protein (YAP) is one of the Hippo pathway's two effectors, a pathway associated with organ size control. Research on YAP has focused on its oncogenic potential. However, in cancer cells, aside from inducing growth, YAP was also found to regulate glucose metabolism. The present review explores YAP's control of glucose metabolism and whether these findings are translatable to physiological conditions. According to current literature, YAP induces the transcriptional activity of most ...
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#1Marc-Sebastian F Straka (University of Cambridge)
#2Noha Abdullah Al-Otaibi (University of Cambridge)
Last. Hassan Rahmoune (University of Cambridge)H-Index: 34
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BACKGROUND/AIMS The use of novel cryo-additive agents to increase cell viability post-cryopreservation is paramount to improve future cell based-therapy treatments. We aimed to establish the Human Leukemia (HL-60) cells lipidomic and biological patterns when cryo-preserved in DMSO alone and with 300 µM Nigerose (Nig), 200 µM Salidroside (Sal) or a combination of Nig (150 µM) and Sal (100 µM). METHODS HL-60 cells were pre-incubated with Nig/Sal prior, during and post cryopreservation, and subject...
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