Original paper
Overexpression of Tet3 in donor cells enhances goat somatic cell nuclear transfer efficiency
Abstract
Ten-eleven translocation 3 (TET3) mediates active DNA demethylation of paternal genomes during mouse embryonic development. However, the mechanism of DNA demethylation in goat embryos remains unknown. In addition, aberrant DNA methylation reprogramming prevalently occurs in embryos cloned by somatic cell nuclear transfer (SCNT). In this study, we reported that TET3 is a key factor in DNA demethylation in goat pre-implantation embryos. Knockdown...
Paper Details
Title
Overexpression of Tet3 in donor cells enhances goat somatic cell nuclear transfer efficiency
Published Date
Jun 8, 2018
Journal
Volume
285
Issue
14
Pages
2708 - 2723
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Notes
History