Isofraxisecoside, a new coumarin-secoiridoid from the stem bark of Fraxinus xanthoxyloides.

Published on May 1, 2019in Natural Product Research2.158
· DOI :10.1080/14786419.2018.1475379
Aldjia Hadroug1
Estimated H-index: 1
Rachid Belhattab1
Estimated H-index: 1
+ 1 AuthorsParaskev T. Nedialkov13
Estimated H-index: 13
(Sofia Medical University)
A new coumarin-secoiridoid diglucoside, named Isofraxisecoside, was isolated from the stem bark of Fraxinus xanthoxyloides (G. Don) Wall. ex A. DC. along with nine known compounds. The stru...
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#2Xiao-Dan Ren (Tianjin University of Science and Technology)H-Index: 5
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A new natural compound, esculetin-5-O-β-D-glucopyranoside (1), along with two known flavonoids, quercetin (2) and kaempferol-3-β-D-glucopyranoside (3), was purified from the heartwood of Fraxinus velutina. Their chemical structures were elucidated by spectroscopic methods, including extensive 1D and 2D NMR, and MS techniques.
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One new, namely 6-methoxykaempferol 3-O-[β-apiofuranosyl(l-->2)]-f-glucopyranosyl(l->6)-fl-glucopyranoside (2), and two known flavonoid glycosides, spinacetin 3-O-[β-apiofuranosyl(1-->2)]-β-glucopyranosyl(1-->6)-β-glucopyranoside (1) and spinacetin 3-O-gentiobioside (3), were isolated from the roots of Chenopodium bonus-henricus L. Their structures were determined by means of spectroscopic methods (ID, 2D NMR, UV, IR) and HR-ESI-MS. Radical scavenging and anti-oxidant activities of 1 and 3 were ...
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In this paper, a chromatographic method for isolation and purification of coumarin compounds from Cortex fraxinus was established by using Superose 12 as the separation media for the first time. The conditions for separation were optimized. Four kinds of coumarin compounds including aesuletin, aesculin, fraxetin and fraxin were obtained. The purity of these compounds were 98.5, 99.1, 97.9 and 97.3%, respectively, which were determined by HPLC area normalization method. The chemical structures of...
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Chemical studies on the roots of Fraxinus rhynchophylla led to the isolation of fraxisecoside (1), a novel coumarin–secoiridoid hybrid glycoside, namely, fraxetin-8-O-[11′-methyl-oleosidyl-(7′ → 6″)]-β-d-glucopyranoside and 14 known compounds. Their structures were elucidated based on chemical evidence and spectroscopic analysis, including extensive 2D NMR methods. Compound 2 was first isolated as a pure compound. Compound 1 exhibited moderate PTP1B inhibition activity. Compounds 1 and 2 showed ...
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Abstract Ten previously undescribed glycosides, carissaedulosides A-J (1-10) referring to six apiosylated phenylpropanoids (1-6), one coumarin-secoiridoid hybrid (7), and three furofuran lignans (8-10) were isolated from the root barks of Carissa edulis, together with 13 known analogues (11-23). Their structures were elucidated by spectroscopic analysis, ECD computational methods, and chemical derivations for configurations of sugar moieties. The new lignan bisdesmoside, 10, exhibited significan...
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Abstract In the quest to search and discover bioactive compounds from nature, terpenoids have emerged as one of the most interesting and researched classes of compounds. Secoiridoid, a type of the terpenoid, has also been extensively studied, especially their chemical structures and pharmacological effects. Oleaceae is a family of woody dicotyledonous plants with broad economic and medicinal values. This family contains a large number of flavonoids, monoterpenoids, iridoids, secoiridoids and phe...
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