The role of necroptosis in non-alcoholic fatty liver disease-related carcinogenesis

Necroptosis is a highly immunogenic regulated cell death routine that depends on receptor-interacting protein 3 (RIP3) kinase activity. We aimed to evaluate the role of necroptosis in the pathogenesis of nonalcoholic fatty liver disease (NAFLD)-driven carcinogenesis. C57BL/6 wild-type (WT) or RIP3-deficient (RIP3-/-) mice were fed a choline-deficient L-amino acid-defined diet (CDAA; n= 14) or an isocaloric control diet (CSAA; n= 14) diet for 66...