Free Radical Biology and Medicine
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#1Etsuo Niki (UTokyo: University of Tokyo)H-Index: 74
Abstract null null Lipids are oxidized in vivo by multiple oxidizing species with different properties, some by regulated manner to produce physiological mediators, while others by random mechanisms to give detrimental products. Vitamin E plays an important role as a physiologically essential antioxidant to inhibit unregulated lipid peroxidation by scavenging lipid peroxyl radicals to break chain propagation independent of the type of free radicals which induce chain initiation. Kinetic data sug...
#1Brian Head (Linus Pauling Institute)
#2Maret G. Traber (OSU: Oregon State University)H-Index: 89
Abstract null null This review discusses why the embryo requires vitamin E (VitE) and shows that its lack causes metabolic dysregulation and impacts morphological changes at very early stages in development, which occur prior to when a woman knows she is pregnant. VitE halts the chain reactions of lipid peroxidation (LPO). Metabolomic analyses indicate that thiols become depleted in E− embryos because LPO generates products that require compensation using limited amino acids and methyl donors th...
#1Gabriele Bluemel (Medical University of Graz)
#2Mélanie Planque (Katholieke Universiteit Leuven)H-Index: 7
Last. Katharina Leithner (Medical University of Graz)H-Index: 17
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Abstract null null Cancer cells frequently lack nutrients like glucose, due to insufficient vascular networks. Mitochondrial phosphoenolpyruvate carboxykinase, PCK2, has recently been found to mediate partial gluconeogenesis and hence anabolic metabolism in glucose starved cancer cells. Here we show that PCK2 acts as a regulator of mitochondrial respiration and maintains the redox balance in nutrient-deprived human lung cancer cells. PCK2 silencing increased the abundance and interconversion of ...
#1Venkata Krishna Kanth Makani (AcSIR: Academy of Scientific and Innovative Research)H-Index: 6
#2Jolly Janette Mendonza (Indian Institute of Chemical Technology)
Last. Manika Pal Bhadra (Indian Institute of Chemical Technology)H-Index: 22
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Abstract null null The cancer-testis antigen CTCFL/BORIS (Brother of Regulator of Imprinted Sites) also known, as a paralog of CTCF -the “master weaver of the genome” is a key transcriptional regulator. Both CTCF and BORIS can bind to the same promoter sequence and recruit diverse proteins. BORIS is also known to be associated with actively translating ribosomes suggesting new roles of BORIS in gene expression. Various studies have attempted to elucidate the role of BORIS in different cell types...
The name vitamin E, was given by Barnett and Sure who suggested that the factor proposed by Evans and Bishop as substance "X," be termed vitamin "E" as the next vitamin after the A, B, C and D vitamins had been already described. The identification of vitamin E with a-tocopherol was made in 1936 by Evans' group. One year later β-tocopherol and 11 years later δ-tocopherol were isolated. Tocotrienol (named zetatocopherol) was first described in 1957 and later isolated in 1961. The antioxidant prop...
#1Shaoqing Li (Capital Medical University)H-Index: 1
#2Wei An (Capital Medical University)H-Index: 1
Last. Lizheng Qin (Capital Medical University)H-Index: 9
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Abstract null null Over 80% of patients undergoing radiotherapy (RT) for head and neck cancer (HNC) suffer reduced saliva secretion and dry mouth symptoms due to salivary gland damage. Although therapeutic interventions to alleviate such RT-induced damage are available, long-term hypofunction remains a significant issue. Therefore, novel therapeutic solutions to prevent irradiation (IR)-induced salivary gland damage are required. This study explored the protective effect of inorganic nitrate in ...
#1Qiaoting Hu (Fujian Medical University)
#2Mingyu Liu (Guangzhou Medical University)
Last. Kangshun Zhu (Guangzhou Medical University)H-Index: 21
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Abstract null null Hepatic stellate cells (HSCs) play key roles in liver fibrosis (LF) and hepatocellular carcinoma (HCC). We previously reported that spleen tyrosine kinase (SYK) is critical for HSCs activation, however, the mechanisms are insufficiently understood. In the present study, we found that SYK facilitated autophagy to promote HSCs activation by enhancing reactive oxygen species (ROS) generation. However, SYK inhibitor GS-9973 could efficiently reduce HSCs ROS generation in vitro but...
#1Sophia R.L. Vieira (UCL: University College London)H-Index: 2
#2Anthony H.V. Schapira (UCL: University College London)H-Index: 127
Abstract null null Biallelic (homozygous or compound heterozygous) glucocerebrosidase gene (GBA) mutations cause Gaucher disease, whereas heterozygous mutations are numerically the most important genetic risk factor for Parkinson disease (PD) and are associated with the development of other synucleinopathies, notably Dementia with Lewy Bodies. This phenomenon is not limited to GBA, with converging evidence highlighting further examples of autosomal recessive disease genes increasing neurodegener...
#1Paul W Buehler (UMD: University of Maryland, College Park)H-Index: 4
#2Delaney C. Swindle (University of Colorado Denver)H-Index: 3
Last. Thomas Gentinetta (CSL Behring)H-Index: 3
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Abstract null null Hemopexin (Hpx) is a crucial defense protein against heme liberated from degraded hemoglobin during hemolysis. High heme stress creates an imbalance in Hpx bioavailability, favoring heme accumulation and downstream pathophysiological responses leading to cardiopulmonary disease progression in sickle cell disease (SCD) patients. Here, we evaluated a model of murine SCD, which was designed to accelerate red blood cell sickling, pulmonary hypertension, right ventricular dysfuncti...
#1Yoshiro Saito (LMB: Laboratory of Molecular Biology)H-Index: 48
Abstract null null Vitamin E, a generic term for tocopherol (T) and tocotrienol (T3), is one of the most potent lipid-soluble antioxidants in the body. It is classified into T and T3 based on the difference in the side chain structure. T and T3 have four isoforms: α-, β-, γ-, and δ, which have different chroman rings. Both T and T3 exhibit a similar ability to scavenge free radicals, and the extent of this ability depends on the difference in the chroman structure. However, they display unique c...
Top fields of study
Oxidative stress
Reactive oxygen species
Diabetes mellitus
Cell biology