Original paper

RNA-guided transcriptional silencing in vivo with S. aureus CRISPR-Cas9 repressors

Volume: 9, Issue: 1
Published: Apr 26, 2018
Abstract
CRISPR-Cas9 transcriptional repressors have emerged as robust tools for disrupting gene regulation in vitro but have not yet been adapted for systemic delivery in adult animal models. Here we describe a Staphylococcus aureus Cas9-based repressor (dSaCas9 KRAB ) compatible with adeno-associated viral (AAV) delivery. To evaluate dSaCas9 KRAB efficacy for gene silencing in vivo, we silenced transcription of Pcsk9 , a regulator of cholesterol...
Paper Details
Title
RNA-guided transcriptional silencing in vivo with S. aureus CRISPR-Cas9 repressors
Published Date
Apr 26, 2018
Volume
9
Issue
1
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