Profiling human breast epithelial cells using single cell RNA sequencing identifies cell diversity
Abstract
Breast cancer arises from breast epithelial cells that acquire genetic alterations leading to subsequent loss of tissue homeostasis. Several distinct epithelial subpopulations have been proposed, but complete understanding of the spectrum of heterogeneity and differentiation hierarchy in the human breast remains elusive. Here, we use single-cell mRNA sequencing (scRNAseq) to profile the transcriptomes of 25,790 primary human breast epithelial...
Paper Details
Title
Profiling human breast epithelial cells using single cell RNA sequencing identifies cell diversity
Published Date
May 23, 2018
Journal
Volume
9
Issue
1
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