Fungal pathogen

Virulence

Biochemistry

Amphotericin B

Caspofungin

Fluconazole

Voriconazole

Candida albicans

Microbiology

Biology

Gene

Pathogen

Botany

Antifungal

Galleria mellonella

Fungus

Candida auris

Emerging Microbes & Infections

The emerging human fungal pathogen Candida auris has been recognized as a multidrug resistant species and is associated with high mortality. This fungus was first described in Japan in 2009 and has been reported in at least 18 countries on five continents. In this study, we report the first isolate of C. auris from the bronchoalveolar lavage fluid (BALF) of a hospitalized woman in China. Interestingly, this isolate is susceptible to all tested antifungals including amphotericin B, fluconazole, and caspofungin. Copper sulfate (CuSO4) also has a potent inhibitory effect on the growth of this fungus. Under different culture conditions, C. auris exhibits multiple morphological phenotypes including round-to-ovoid, elongated, and pseudohyphal-like forms. High concentrations of sodium chloride induce the formation of a pseudohyphal-like form. We further demonstrate that C. auris is much less virulent than Candida albicans in both mouse systemic and invertebrate Galleria mellonella models.

The first isolate of <i>Candida auris</i> in China: clinical and biological aspects

The first isolate of Candida auris in China: clinical and biological aspects