Bioadhesive, Hemostatic, and Antibacterial in Situ Chitin–Fibrin Nanocomposite Gel for Controlling Bleeding and Preventing Infections at Mediastinum

Mediastinitis occurs after cardiac surgery and is a major threat to patient's life due to postoperative bleeding and deep sternal wound infection. Major challenge in treating this condition is that it demands a material that should adhere to the applied site and act as both a hemostatic and an antibacterial agent. On the basis of this we have developed an in situ forming tissue adhesive chitin–fibrin (CH-FB) gel with tigecycline loaded gelatin...