Developmental and oncogenic programs in H3K27M gliomas dissected by single-cell RNA-seq
Abstract
The cellular composition of H3K27M gliomas Diffuse midline gliomas with histone H3 lysine27-to-methionine mutations (H3K27M-glioma) are an aggressive type of childhood cancer with few options for treatment. Filbin et al. used a single-cell sequencing approach to study the oncogenic programs, genetics, and cellular hierarchies of H3K27M-glioma. Tumors were mainly composed of cells resembling oligodendrocyte precursor cells, whereas differentiated...
Paper Details
Title
Developmental and oncogenic programs in H3K27M gliomas dissected by single-cell RNA-seq
Published Date
Apr 20, 2018
Journal
Volume
360
Issue
6386
Pages
331 - 335
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