Multi-nucleated cells use ROS to induce breast cancer chemo-resistance in vitro and in vivo
Abstract
Although there is a strong correlation between multinucleated cells (MNCs) and cancer chemo-resistance in variety of cancers, our understanding of how multinucleated cells modulate the tumor micro-environment is limited. We captured multinucleated cells from triple-negative chemo-resistant breast cancers cells in a time frame, where they do not proliferate but rather significantly regulate their micro-environment. We show that oxidatively...
Paper Details
Title
Multi-nucleated cells use ROS to induce breast cancer chemo-resistance in vitro and in vivo
Published Date
May 10, 2018
Journal
Volume
37
Issue
33
Pages
4546 - 4561
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