Translational pathway of scalable, allogenic encapsulated Mesenchymal Stem Cells for Dental Pulp Regeneration. RanoKure a controlled Phase I/II clinical trial designed to evaluate the survival of mature permanent teeth with apical lesion following a regenerative endodontics procedure

In view of the increasing demand to maintain pulpal vitality and the high cost of endodontic treatments, there is a great interest in investigating new methods for the replacement of damaged tissues through the use of tissue engineering. The main goal of regenerative endodontics (RE) is to revitalize teeth by the regeneration of healthy dental pulp using combined tissue engineering approaches. Despite the fact that these dental health conditions...