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#1Renata Gilfanova (Pacific Research Institute)H-Index: 1
#2Kirsten M. Auclair (Pacific Research Institute)
Last. Marcus O. Muench (Pacific Research Institute)H-Index: 41
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Abstract null Background aims null The cryopreservation of hematopoietic stem cells (HSCs) in dimethyl sulfoxide (DMSO) is used widely, but DMSO toxicity in transplant patients and the effects of DMSO on the normal function of cryopreserved cells are concerns. To address these issues, in vitro and clinical studies have explored using reduced concentrations of DMSO for cryopreservation. However, the effect of reducing DMSO concentration on the efficient cryopreservation of HSCs has not been direc...
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#1Smitha Mathews (UHN: University Health Network)
#2R. Rabani (UHN: University Health Network)H-Index: 2
Last. Sowmya ViswanathanH-Index: 19
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Abstract null null Background aims null In this study, the authors performed an in-house abbreviated qualification of a commercially available real-time polymerase chain reaction (PCR) kit for limit of detection (LOD), matrix interference and ruggedness of mycoplasma detection in a human bone marrow-derived mesenchymal stromal cell (MSC(M)) investigational cell product (NCT02351011). The approach used was similar to an abbreviated qualification the authors previously conducted for endpoint PCR, ...
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#1Rongxia Guo (Peking Union Medical College)H-Index: 4
#2Xiaoyu Zhang (Peking Union Medical College)H-Index: 5
Last. Fengxia Ma (Peking Union Medical College)H-Index: 15
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Abstract null null Background aims null Hematopoietic stem and progenitor cells (HSPCs) are known to produce short-lived mature blood cells via proliferation and differentiation in a process that depends partially on regulatory cytokines from the bone marrow (BM) microenvironment. Delayed BM recovery after tremendous damage to the hematopoietic system can lead to neutropenia, anemia, thrombopenia and even death. However, efficiently promote BM recovery is still a big problem to be solved. Here, ...
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#1Daniel P CollinsH-Index: 2
#2Mark J. Osborn (UMN: University of Minnesota)H-Index: 24
Last. Clifford J. Steer (UMN: University of Minnesota)H-Index: 72
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Abstract null null Along with the nasal epithelium, the lung epithelium is a portal of entry for sudden acute respiratory syndrome coronavirus-2 (SARS-CoV-2) and many other respiratory viruses. In the case of SARS-CoV-2, the virus surface spike proteins bind to the ACE-2 receptor to facilitate entry into respiratory epithelium. Alveolar type 2 (AT2) cells are committed respiratory progenitor cells responsible for the integrity and regeneration of the respiratory epithelium and production of resp...
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#1Jeffrey M.H. Liu (Stanford University)H-Index: 7
#2Ping (Pauline) Chen (Stanford University)H-Index: 1
Last. Maria Grazia Roncarolo (Stanford University)H-Index: 104
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Abstract null null Background aims null Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is a curative therapeutic approach for many hematological disorders. However, allo-HSCT is frequently accompanied by a serious side effect: graft-versus-host disease (GVHD). The clinical use of allo-HSCT is limited by the inability of current immunosuppressive regimens to adequately control GvHD without impairing the graft-versus-leukemia effect (GvL) conferred by transplanted healthy immune ce...
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#1Madison C.B. Paton (Cerebral Palsy Alliance)
#2Donna A. Wall (U of T: University of Toronto)H-Index: 33
Last. Megan Finch-Edmondson (Cerebral Palsy Alliance)
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Abstract null null Background aims null Umbilical cord blood (UCB) infusion is being investigated as a treatment for a range of neurological conditions, primarily because of its potent immunomodulatory effects mediated via paracrine signaling. Although initial research mainly utilized autologous UCB, allogeneic samples from a sibling or unrelated donor have now become more common. With the use of allogeneic UCB, questions have arisen surrounding the necessity for human leukocyte antigen (HLA) ma...
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#1Julia A Riedl (UMN: University of Minnesota)H-Index: 2
#2Courtney Popp (UMN: University of Minnesota)
Last. Jakub Tolar (UMN: University of Minnesota)H-Index: 63
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Mesenchymal stromal cells (MSCs) are multi-potent stromal-derived cells capable of self-renewal that possess several advantageous properties for wound healing, making them of interest to the field of dermatology. Research has focused on characterizing the unique properties of MSCs, which broadly revolve around their regenerative and more recently discovered immunomodulatory capacities. Because of ease of harvesting and expansion, differentiation potential and low immunogenicity, MSCs have been l...
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#1Rutvij A. Khanolkar (U of C: University of Calgary)
#2Amit Kalra (U of C: University of Calgary)H-Index: 4
Last. Faisal Khan (U of C: University of Calgary)H-Index: 29
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Abstract null null Background aims null Intensified immunosuppressive prophylaxis for graft-versus-host disease (GVHD) may be toxic and therefore warranted only in patients at high risk of developing GVHD. In patients who underwent allogeneic hematopoietic cell transplant at the authors’ center, high serum soluble IL-2 receptor alpha (sIL-2Rα) and low IL-15 levels on day 7 post-transplant were found to predict a high risk of developing clinically significant GVHD (sGVHD), defined as grade 2–4 ac...
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#1Evelyn Yun Xi Loh (Ministry of Health (Malaysia))
#2Pick Sim Goh (Ministry of Health (Malaysia))H-Index: 1
Last. Azizah Ab Ghani (Ministry of Health (Malaysia))H-Index: 1
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Abstract null null Background aims null Cell and gene therapy products (CGTPs) are anticipated to bring many benefits for the treatment of conditions with limited or no satisfactory treatment options. However, they are associated with concerns of potential safety risks because of their high complexity. The National Pharmaceutical Regulatory Agency (NPRA) of Malaysia took the first step toward the regulation of CGTPs by publishing the Malaysian Guidance Document and Guidelines for CGTPs in 2016. ...
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#1Achi Kamaraj (University of Cambridge)H-Index: 2
#2Harry Kyriacou (University of Cambridge)H-Index: 1
Last. Wasim S. Khan (University of Cambridge)H-Index: 38
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BACKGROUND AIMS Articular cartilage has limited regenerative ability when damaged through trauma or disease. Failure to treat focal chondral lesions results in changes that inevitably progress to osteoarthritis. Osteoarthritis is a major contributor to disability globally, which results in significant medical costs and lost wages every year. Human induced pluripotent stem cells (hiPSCs) have long been considered a potential autologous therapeutic option for the treatment of focal chondral lesion...
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