Targeting Cytosolic Nucleic Acid-Sensing Pathways for Cancer Immunotherapies
Abstract
The innate immune system provides the first line of defense against pathogen infection though also influences pathways involved in cancer immunosurveillance. The innate immune system relies on a limited set of germ line-encoded sensors termed pattern recognition receptors (PRRs), signaling proteins and immune response factors. Cytosolic receptors mediate recognition of danger damage-associated molecular patterns (DAMPs) signals. Once activated,...
Paper Details
Title
Targeting Cytosolic Nucleic Acid-Sensing Pathways for Cancer Immunotherapies
Published Date
Apr 9, 2018
Journal
Volume
9
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