ME1 Regulates NADPH Homeostasis to Promote Gastric Cancer Growth and Metastasis
Abstract
Genomic alterations of tumor suppressorsoften encompass collateral protein-coding genes that create therapeutic vulnerability to further inhibition of their paralogs. Here, we report that malic enzyme 2 (ME2) is frequently hemizygously codeleted with SMAD4 in gastric cancer. Its isoenzyme ME1 was upregulated to replenish the intracellular reducing equivalent NADPH and to maintain redox homeostasis. Knockdown of ME1 significantly depleted NADPH,...
Paper Details
Title
ME1 Regulates NADPH Homeostasis to Promote Gastric Cancer Growth and Metastasis
Published Date
Apr 12, 2018
Journal
Volume
78
Issue
8
Pages
1972 - 1985
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